Scientists made a new discovery. In studies, cell adhesion molecule 1 (CADM1) 3E1, a new antibody that targets, It draws attention with its side-effects and long-term pain relief effect.. research team, revealed that this antibody could suppress the activity of nerves that transmit pain signals.
Scientists from Kindai University in Japan, revealed a new discovery in their work.According to the news in TRTHaber; Cell adhesion molecule 1 (CADM1) 3E1, a new antibody that targets, It draws attention with its side-effects and long-term pain relief effect. 3E1 antibody, It affects only sensory nerves by targeting the CADM1 protein found on the surface of nerve cells..research team, revealed that this antibody can suppress the activity of nerves that transmit pain signals. Prof from Kindai University Faculty of Medicine. Akihiko Ito and Dr. Study led by Fuka Takeuchi, published his results in the science journal Life Sciences.Within the scope of the study, 3E1 antibody was injected into the skin of mice and it was observed that the antibody was localized only in the sensory nerves under the skin..In chemically induced pain tests, 3It was observed that the pain-related behaviors of E1-treated mice were significantly reduced compared to the control group.. These effects, Lasting much longer than current local anesthetics 24 According to the research team, 3One of the most important advantages of E1 is that it does not have any negative effects on motor nerves..In experiments conducted on mice, the antibody did not cause paralysis or behavioral abnormalities., It was found that it only suppresses the perception of pain.Prof. This, “Discovery of an antibody that accumulates in nerves with an injection and provides a pain-relieving effect, He emphasized the importance of the study by saying, "It may open the doors to a new field called 'antibody anesthetics'."Antibody-based drugs developed in recent years to treat osteoarthritis and chronic pain, had limited success due to serious side effects. But 3E1, It offers a safe alternative without affecting motor nerves and creating toxic effects. Researchers, He stated that they are working on versions of the antibody that provide longer-lasting effects to make it suitable for use in humans.. This new treatment method, shows promise for chronic pain and other pain-related conditions.
